Transcription initiation protein SPT3 homolog

Suppressor of Ty 3 homolog (S. cerevisiae)

Identifiers

SUPT3H; SPT3; SPT3L

External IDs

OMIM: 602947 MGI: 1923723 HomoloGene: 121570 GeneCards: SUPT3H Gene

Gene Ontology
Molecular function	• DNA binding • transcription coactivator activity • histone acetyltransferase activity
Cellular component	• nucleus • nucleolus • STAGA complex • transcription factor TFTC complex
Biological process	• transcription initiation, DNA-dependent • regulation of transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • histone deubiquitination • histone H3 acetylation • positive regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000196284

ENSMUSG00000038954

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
44.78 – 45.35 Mb

Chr 17:
44.91 – 45.26 Mb

PubMed search

Transcription initiation protein SPT3 homolog is a protein that in humans is encoded by the SUPT3H gene.^[1]^[2]^[3]

Interactions

Transcription initiation protein SPT3 homolog has been shown to interact with GCN5L2,^[4]^[5] TAF6L,^[5] TADA3L,^[5] TAF5L,^[5] SF3B3,^[5] SUPT7L,^[5] Myc,^[6] TAF9,^[5] Transformation/transcription domain-associated protein,^[5] TAF12,^[5] TAF10,^[4]^[5] TAF4^[4] and DDB1.^[5]

References

^ Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (Aug 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425.
^ Martinez E, Kundu TK, Fu J, Roeder RG (Oct 1998). "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID". J Biol Chem 273 (37): 23781–5. doi:10.1074/jbc.273.37.23781. PMID 9726987.
^ "Entrez Gene: SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8464.
^ ^a ^b ^c Brand, M; Moggs J G, Oulad-Abdelghani M, Lejeune F, Dilworth F J, Stevenin J, Almouzni G, Tora L (Jun. 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". EMBO J. (England) 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. ISSN 0261-4189. PMC 150203. PMID 11406595. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=150203.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k Martinez, E; Palhan V B, Tjernberg A, Lymar E S, Gamper A M, Kundu T K, Chait B T, Roeder R G (Oct. 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. (United States) 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. ISSN 0270-7306. PMC 99856. PMID 11564863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99856.
^ Liu, Xiaohui; Tesfai Jerusalem, Evrard Yvonne A, Dent Sharon Y R, Martinez Ernest (May. 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". J. Biol. Chem. (United States) 278 (22): 20405–12. doi:10.1074/jbc.M211795200. ISSN 0021-9258. PMID 12660246.

Further reading

Yu J, Madison JM, Mundlos S, et al. (1998). "Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor spt3 (SUPT3H).". Genomics 53 (1): 90–6. doi:10.1006/geno.1998.5500. PMID 9787080.
Vassilev A, Yamauchi J, Kotani T, et al. (1999). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.". Mol. Cell 2 (6): 869–75. doi:10.1016/S1097-2765(00)80301-9. PMID 9885574.
Brand M, Yamamoto K, Staub A, Tora L (1999). "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.". J. Biol. Chem. 274 (26): 18285–9. doi:10.1074/jbc.274.26.18285. PMID 10373431.
Speek M (2001). "Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes.". Mol. Cell. Biol. 21 (6): 1973–85. doi:10.1128/MCB.21.6.1973-1985.2001. PMC 86790. PMID 11238933. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86790.
Brand M, Moggs JG, Oulad-Abdelghani M, et al. (2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation.". EMBO J. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=150203.
Martinez E, Palhan VB, Tjernberg A, et al. (2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99856.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Cavusoglu N, Brand M, Tora L, Van Dorsselaer A (2003). "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.". Proteomics 3 (2): 217–23. doi:10.1002/pmic.200390030. PMID 12601814.
Liu X, Tesfai J, Evrard YA, et al. (2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation.". J. Biol. Chem. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMID 12660246.